Andie, a 9-year-old terminal cancer patient, is brought in after suffering from a hallucinogenic episode. Wilson convinces House to take the case, but he and his team struggle to diagnose what caused the hallucination. Andie handles the reality of her terminal medical situation remarkably well – so well that House questions the sincerity of her bravery and considers the possibility it may be a medical symptom.

Meanwhile, Andie’s request to experience one of life’s great “firsts” forces Dr. Chase to make a difficult personal decision. House has an idea of what’s causing Andie’s medical emergency, but puts the decision in her hands as to whether to take on an extremely risky experimental treatment, one that may end her life even sooner than her terminal illness.